The Good Samaritan Hospital was organized in 1889 in Charlotte under the auspices of St. Peter's Episcopal Church of that city. It is believed to be the first privately funded hospital in the United States built and operated exclusively for black patients.

The origins of the hospital have been attributed both to the mission philosophy of the Episcopal Church and the determined efforts of St. Peter's clergy and parishioners. Of the latter, Jane Renwick Smedberg Wilkes (1827-1913) was particularly outstanding in her efforts to establish the hospital and to lead other philanthropic activities in the community for more than fifty years. Good Samaritan was erected with funds raised by private subscriptions and by continuous appeals through the Episcopal church papers.

The hospital began operation in 1891 under the governance of a board of managers, all women of St. Peter's Episcopal Church. In 1925, a major addition was built immediately behind the original building which more than doubled the facility's capacity. In the 1930's additional property was acquired, and in 1937 another wing was added, making it at the time a 100-bed hospital with the latest equipment. Staff included 22 nurses, with patients from most of the doctors of the city. By the early 1950's, however, the facilities and staffing were not able to keep pace with the years, and a small church found it increasingly difficult to support a modern hospital, even with monies that had come over the years from the Duke Endowment and the Julius Rosenwald fund.

In 1959, Memorial Hospital (now known as Carolinas Medical Center) agreed to take over Good Samaritan and the hospital continued to serve the purpose for which it was built, under a staff of both white and black doctors. However, during 1960 the Episcopal church gave the hospital to the City of Charlotte, and the hospital came under the supervision of the Memorial Hospital Authority. In June, 1961, the site was formally passed to the ownership of the city. It was used as a hospital until 1982 under the name, Charlotte Community Hospital. Then it functioned for a time as the Magnolias Rest Home. In 1990 the building was demolished to make room for Ericsson Stadium.